Ivermectin

What is Ivermectin?

Ivermectin is an anthelmintic medication used to treat parasitic infections in both animals and human beings. Anthelmintic drugs are a group of medications that work for the treatment of parasitic infections in different areas of the body. Ivermectin successfully achieves its function by killing the parasites or preventing them from reproducing further. It was discovered in 1975 by William Campbell and Satoshi Omura and started being used in 1981. 

Benefits of Ivermectin

Before you buy Ivermectin online or offline, you must know what it is truly capable of doing. In this regard, here are some benefits of Ivermectin.

• Both lice and scabies are skin conditions that impact your life with constant itching. Ivermectin is one of the few medications that enable you to get rid of them successfully. This helps improve your skin and social conditions. A majority of the users buy Ivermectin tablets in the UK for this reason.
• Onchocerciasis is a parasitic infection caused by the black fly that causes nodule formation and harms vision. Ivermectin works on the reproductive system of the parasite and destroys the larvae to prevent the infection from spreading further.
• Intestinal strongyloidiasis is another condition that can result in abdominal pain, heartburn, weight loss, and intermittent episodes of diarrhea and constipation. Ivermectin binds to the muscles and nerve cells and paralyzes them to death.
• It is also used for second-line treatment of conditions like gnathostomiasis- a parasitic infection and treatment of mites.
• It is said to work on the cell wall of the SARS-Covid virus by preventing its replication and breaking down its protective wall with ease.

You can buy Ivermectin in the UK to treat the conditions mentioned above without much hassle.

Ivermectin for Covid 19

Recently, Covid virus resulted in an increased mortality rate among its sufferers; which encouraged the governments of different nations to search for quick and effective measures against the virus. Ivermectin along with Hydroxychloroquine was opted for as a temporary line of treatment after measuring its efficacy through a trial plan. The test result confirmed two outcomes. First, it was effective to some extent in reducing the symptoms of the infection. Second, there is no other alternative with a similar level of effectiveness against the viral infection. But all of these postulations are still under clinical trials and FDA approval has not been provided as yet for both medicines as potential Covid treatment medications. It is dangerous to use Ivermectin medication for anything other than its FDA-approved measures. Human consumption of the veterinary component of Ivermectin for Covid treatment can be potentially life-threatening for the user.

How does Ivermectin work?

Researchers have proved that Ivermectin affects the nerves and muscles of the parasites to achieve its destructive effects. It binds to the chloride channels of their cell membranes responsible for maintaining cell volume and, through the hyperpolarization process, paralyzes it and kills the parasite off. While working on the parasites, it ensures the safety of the human body by not crossing the blood-brain barrier or ligand-gated channels, thereby proving it safe and effective for the treatment of parasitic conditions. In people with a viral infection, Ivermectin works by inhibiting the protein synthesis of the virus that suppresses the immune system of the human body to fight against it. It also prevents the spike protein of the virus from attaching itself to the cell receptors of the human body. Now, one can easily buy Ivermectin for humans in the UK online, even without a prescription.

Ivermectin dose

The ideal dose varies on the basis of disease, age, parasitic condition, and allergy to the first dose if any. Ivermectin is available in doses of 150mcg and 200mcg. For parasitic infection in the intestinal tract, adults between 18-64 years and children between 0-17 years are advised to use 20mcg as a single dose as directed by the physician. For infections in the skin or eyes, 150mcg is required to be used in a single dose. The dose is only for those children whose weight is greater than or equal to 33 pounds (15kgs). It is not recommended for children less than that weight. It is also not recommended in elderly people above the age of 65 years because of the poor rate of metabolism by the liver.

Ivermectin Side effects

Nausea, loss of appetite, stomach pain, and diarrhea are some of the common side effects associated with the use of medications. The use of Ivermectin can sometimes lead to dizziness, itching sensation, and sleepiness with a general feeling of tiredness and loss of energy. Rarely, the side effects may present more intense, like severe ocular problems, inability to control bowel movements, extreme tiredness or dizziness, and may extend to seizures, low blood pressure, and coma. Severe skin reactions in rashes, blisters, and peeled skin with permanent liver and ocular damage have also been recorded in people. Cases of brain problems like unexplained sleepiness and inability to stand have also been observed in people using Ivermectin for Loa Loa infection. So before you buy Ivermectin tablets in the UK, take a doctor’s advice for sure.

Purchasing Ivermectin

Ivermectin is available in the form of oral tablets, creams, and lotions. Only the lotion is available over the counter without requiring any prescription. Topical creams and oral tablets are available only by a physician’s prescription. Soolantra, Stromectol, and Sklice are the prominent available brands of Ivermectin for sale in the UK. The tablets are available in the strength of 12mg and can be obtained by prescription or obtained online. These are the generic versions of the medication and are slightly reduced in effectiveness but cheaper and more easily available than the branded versions. Procuring them from a genuine site will ensure that you get authentic Ivermectin.

Ivermectin uses and storage

It is advisable to take Ivermectin with a full glass of water on an empty stomach. Do not take it with milk, juice or any other liquids. Since this is a treatment option for a parasitic condition, go for regular stool checkups with skin and microfilariae count to check whether the medication has effectively destroyed the parasite. Do not miss the advised dose or overuse the tablet to make up for a missed dose. Overdosing may lead to skin rashes, inability to control body movements, vomiting, and shortness of breath. Consult your physician immediately on the appearance of these symptoms. It is imperative not to stop taking the tablet suddenly but take it till the completion of its course to ensure effective treatment. After using it, store it in a cool and dry place away from the reach of children and pets. Do not store it in the glove compartment of your car or in your zip bag but carry it in your bag always. Contrary to other medications, you can cut or crush it for use without any ensuing complications.

Contraindications

Ivermectin can, at times, cause allergic reactions presenting as skin rashes, swollen tongue or throat with breathing difficulties. Do not use Ivermectin if you are allergic to the medication. If required, consult your practitioner regarding other treatment options for parasitic infection.

Ivermectin should also not be used in people with asthma tendencies as it may worsen the condition. There are no research articles as yet proving that the medication is safe for pregnant or breastfeeding women. This should be taken into consideration while starting the dose.

The liver metabolizes Ivermectin. Because of this, it is contraindicated in people with liver dysfunctions or infections and in elderly people whose metabolism rate is slower than others. Additionally, it should not be used in people with immunodeficiency problems like that of HIV as well as in people with seizure problems.

Drug Interactions

Ivermectin has been known to interact with pediculicides, i.e. an agent that destroys lice and a few anticancer medications when combined together. Interactions with the former lead to an increase in the serum concentrations of Ivermectin and increase the risk of toxicity and systemic conditions associated with it.

Anticancer medications, namely Abemaciclib and Abiraterone, decrease the metabolic rates of Ivermectin. Even Anticoagulants that are used to treat ischemic diseases and prevent thromboembolism tend to react with Ivermectin when combined together. This leads to a decrease in the metabolic rate of the medications and reacts with their effectiveness.

The risk of myopathy (problem-related to muscle movements) and hemoglobinuria (a condition leading to the destruction of the red blood cells) is increased when Ivermectin is combined with Acipimox, a medication used to treat hyperlipoproteinemia. Benzylpenicillin- an antibiotic – and Bempedoic- acid, a CAD medication- are two other medications that result in decreased metabolism rate on being combined with Ivermectin.

FDA status

The FDA approved Ivermectin in the 1980s for the treatment of parasitic conditions like Onchocerciasis and Strongyloidiasis. The WHO has even listed Ivermectin as an essential medicine, ranking 420th in the list of most prescribed medications in 2018. But the FDA approval has not yet been extended for the use of Ivermectin for Covid infection. The reason behind the WHO’s concerns is that the amount of medication required for the Covid virus is much more than the prescribed dose. The side effects related to overusing the medication can be more than the effect produced by the medication on Covid-19 positive patients. Despite this statement, the use of the medication in Covid-19 positive patients has been authorized by a few countries to help fight the pandemic more effectively.